The products in clinical development at Pharmacyclics, Inc. (Nasdaq: PCYC) include PCI-32765, an orally active small molecule inhibitor of Bruton's tyrosine kinase (Btk), which is in phase II studies for the treatment of patients with B-cell lymphoma or leukemia; PCI-27483, an inhibitor of Factor VIIa, which is in phase II clinical trial for the treatment of pancreatic cancer; PCI-24781, a histone deacetylase (HDAC) inhibitor in phase I and II clinical trials in solid tumors and hematological malignancies; HDAC8 Isoform-specific Inhibitor for T-cell leukemia and lymphoma, neuroblastoma, and autoimmune disease.



Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, announced yesterday that it has executed an agreement with Pharmacyclics, Inc. to jointly develop and market the anti-cancer compound, PCI-32765. A number of Phase 1 and 2 studies with PCI-32765 are ongoing across a panel of B-cell malignancy disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and diffuse large B-cell lymphoma. Interim data were reported at the 2011 American Society of Clinical Oncology Annual Meeting and oral presentations on two separate Phase 2 studies will be presented at the upcoming American Society of Hematology Meeting in December, along with several other poster presentations.

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