Hemorrhoids are a common anal disorder characterized by bleeding, itching, pain, swelling, tenderness, and difficulty with defecating. Hemorrhoids are pathologic dilatations of the normal vascular beds in the anal and rectal regions. Although the exact mechanism for hemorrhoid formation is unclear, progressive occlusion of venous exit vessels (as can occur in straining during defecation, heavy lifting, and pregnancy) is thought to produce stretching of vessels and vascular stasis.

An anal fissure is a crack in the skin of the anal canal. Typical symptoms are severe pain and bleeding with or after bowel movements. Although hypertonia, which is an increase in tightness of muscle tone of the internal anal sphincter, is associated with anal fissures, its contribution to the cause of fissure remains unclear.





Ventrus BioSciences, Inc. (Nasdaq:VTUS) announced that on November 14, 2011 it completed its acquisition of all rights and title to VEN 309 (iferanserin) from the licensor, Sam Amer & Co.

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